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Neuroendocrine Tumours Evidence Update September 2023   Contents Systematic Reviews Controlled Clinical Trials Guidance Review Articles Qualitative Studies COVID-19 NICE Cochrane Other items of interest   This Evidence Update is useful to me   Request a literature search   Systematic reviews Tumour-specific mesorectal excision for rectal cancer: Systematic review and meta-analysis of oncological and functional outcomes. Clinicoradiological Factors Predicting Lymph Node Metastasis in Patients with Nonfunctioning Pancreatic Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis. Safety and Efficacy of Endoscopic Ultrasound-guided Radiofrequency Ablation for Pancreatic Neuroendocrine Neoplasms: Systematic Review and Meta-analysis. The assessment of Ki-67 for prognosis of gastroenteropancreatic neuroendocrine neoplasm patients: a systematic review and meta-analysis. Feasibility of Home Parenteral Nutrition in Patients with Intestinal Failure Due to Neuroendocrine Tumours: A Systematic Review. PET/CT and Conventional Imaging for the Assessment of Neuroendocrine Prostate Cancer: A Systematic Review. Duodenum-Preserving Pancreatic Head Resection for Benign and Premalignant Tumors-a Systematic Review and Meta-analysis of Surgery-Associated Morbidity. Genetic and epigenetic prognosticators of neuroendocrine tumours of the GI tract, liver, biliary tract and pancreas: A systematic review and meta-analysis. Radiotherapy in the management of rare gastrointestinal cancers: A systematic review. A Systematic Review of Surgical Management Strategies in the Treatment of Peritoneal Carcinomatosis of Neuroendocrine Origin. Peptide receptor radionuclide therapy in advanced Pheochromocytomas and Paragangliomas: a systematic review and meta-analysis. A Comparison of the Outcomes of Transarterial Chemoembolization and Transarterial Radioembolization in the Management of Neuroendocrine Liver Metastases in Adults: A Systematic Review. Detecting undetectable - epidemiology, etiology, and diagnosis of carcinoma of unknown primary - systematic review.   Clinical Trials A phase II study of bevacizumab and temsirolimus in advanced extra-pancreatic neuroendocrine tumors. ILUSTRO: Phase II Multicohort Trial of Zolbetuximab in Patients with Advanced or Metastatic Claudin 18.2-Positive Gastric or Gastroesophageal Junction Adenocarcinoma. A novel nomogram and risk stratification system predicting the cancer-specific survival of patients with gastric neuroendocrine carcinoma: a study based on SEER database and external validation. Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer. Association between gene expression signatures and clinical outcomes of pembrolizumab versus paclitaxel in advanced gastric cancer: exploratory analysis from the randomized, controlled, phase III KEYNOTE-061 trial. Panitumumab plus trifluridine/tipiracil as anti-EGFR rechallenge therapy in patients with refractory RAS wild-type metastatic colorectal cancer: Overall survival and subgroup analysis of the randomized phase II VELO trial.   Guidance Relation between WHO classification and location- and functionality-based classifications of neuroendocrine neoplasms of the digestive tract. Systemic Therapy for Tumor Control in Metastatic Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline. Systemic Therapy for Tumor Control in Well-Differentiated Metastatic Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline Q and A. European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for appendiceal neuroendocrine tumours (aNET). European Neuroendocrine Tumor Society 2023 guidance paper for functioning pancreatic neuroendocrine tumour syndromes.   Review Articles An Overview of Circulating Biomarkers in Neuroendocrine Neoplasms: A Clinical Guide. Experience with 177Lu-Dotatate in Patients with Metastatic Gastroenteropancreatic Neuroendocrine Tumors at a Single Urban Cancer Center. Targeting Key Players of Neuroendocrine Differentiation in Prostate Cancer. Prognostic Assessment of Gastropancreatic Neuroendocrine Neoplasm: Prospects and Limits of Radiomics. Narrative Review of Immunotherapy in Gastroentero-Pancreatic Neuroendocrine Neoplasms. Promising targetable biomarkers in pancreatic neuroendocrine tumours. Surgical approach to achieve R0 resections in primary and metastatic liver tumors: a literature review. Role of stress in the pathogenesis of cancer (Review). Gastroenteropancreatic Neuroendocrine Tumors-Current Status and Advances in Diagnostic Imaging. An integrative view on glucagon function and putative role in the progression of pancreatic neuroendocrine tumours (pNETs) and hepatocellular carcinomas (HCC). Management of neuroendocrine tumor liver metastases. Role of Advanced Gastrointestinal Endoscopy in the Comprehensive Management of Neuroendocrine Neoplasms. Combination Systemic Therapies in Advanced Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs): A Comprehensive Review of Clinical Trials and Prospective Studies. An Overview of Pancreatic Neuroendocrine Tumors and an Update on Endoscopic Techniques for Their Management. Gastrointestinal Neuroendocrine Tumors and the Carcinoid Syndrome. A review of contrast-enhanced harmonic endoscopic ultrasonography for pancreatic solid tumors. Long-acting somatostatin analogs and well differentiated neuroendocrine tumors: a 20-year-old story. Models in Pancreatic Neuroendocrine Neoplasms: Current Perspectives and Future Directions. A Comprehensive Review on Neuroendocrine Neoplasms: Presentation, Pathophysiology and Management. Virus-associated neuroendocrine cancers: Pathogenesis and current therapeutics. Grade Progression and Intrapatient Tumor Heterogeneity as Potential Contributors to Resistance in Gastroenteropancreatic Neuroendocrine Tumors. Prognostic Implications of PET-Derived Tumor Volume and Uptake in Patients with Neuroendocrine Tumors. Progress in immunotherapy for neuroendocrine neoplasm of the digestive system. Developments in interventional management of hepatic metastases from neuroendocrine tumours.   Qualitative Studies Patient Experiences After Aborted Cancer Surgery: A Qualitative Study.     For up-to-date articles, click here: PubMed NET search     Artificial intelligence technologies to aid contouring for radiotherapy treatment planning: early value assessment Suspected cancer: recognition and referral Pembrolizumab for previously treated endometrial, biliary, colorectal, gastric or small intestine cancer with high microsatellite instability or mismatch repair deficiency Oesophago-gastric cancer: assessment and management in adults     Hyperbaric oxygen therapy for late radiation tissue injury     UK and Ireland Neuroendocrine Tumour Society Latest research news Current Clinical Trials Latest News     NET Patient Foundation News from the NET Patient Foundation (click for updates)     To access full text you may have to log in to your NHS Athens account (click here to register for free). If full text is not available then please email us to request a copy.   Leicester Publications   Search PubMed for up to date Leicester Publications   This Evidence Update is NOT useful to me Request a literature search      View our other Evidence Updates Our mailing address is: pip.divall@uhl-tr.nhs.uk This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.   Share Tweet Forward